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⚡ Unlock radiant skin with the power of 15M exosomes — don’t miss the glow-up!
Medicube Exosome Shot Zero is a cutting-edge facial serum featuring 25,000 PPM concentration and 15 million patented exosome shots delivered via micro-sized spicules. This Korean skincare innovation combines AHA, BHA, and PHA acids to exfoliate and refine pores, promoting smoother, revitalized skin texture. Designed for all skin types, it offers intensive pore care with a unique tingling sensation signaling active skin renewal, perfect for a weekly skincare boost.

| ASIN | B0DQW3P7VX |
| Active Ingredients | Lacto Exosome, AHA, BHA, PHA |
| Best Sellers Rank | #682 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #24 in Facial Serums |
| Brand | medicube |
| Brand Name | medicube |
| Customer Reviews | 4.4 out of 5 stars 529 Reviews |
| Item Form | Ampoule |
| Item Highlight | Liquid Skin Booster Serum with Exosome, AHA+BHA+PHA - Pore Care, Dead Skin Cells, Skin Texture, Korean Skincare, 0.43 fl.oz |
| Item Volume | 13 ml |
| Item Weight | 13 milligrams |
| Manufacturer | Medicube |
| Manufacturer Part Number | PMEKR14040 |
| Model Number | PMEKR14040 |
| Number of Items | 1 |
| Product Benefits | Hydrating, Pore Treatment, Skin texture |
| Skin Type | All |
| Special Ingredients | Lacto Exosome, AHA, BHA, PHA |
| Target Use Body Part | Face |
| Use for | Face |
J**N
Astounding Results!
I used this product the night after receiving it. I can't say at the time of ordering that I was convinced as other reviewers mentioned, "It's as good as microneedling. I microneedle about once per month in hopes that my skincare actives with absorb deeper into the skin. I have seen slight improvements from this process. I was intrigued by the Medicube Exosome Shot. Most of the reviews were positive, and since the emphasis was on treating large pores, I finally decided to give the product a try. First of all, unlike microneedling, there was no discomfort for me. There was a mild prickly sensation that I did not find unpleasant. Quite the opposite, I found the sensation comfortable, as well as promising because it was indicative that the product was actually performing. I have the stronger 25000 shot as advised by another reviewer. First, I cleansed my face and patted dry. I followed up with low strength glycolic pads to remove any residual makeup. After rinsing and patting dry again, I proceeded with my first Exosome treatment. It did take numerous pumps before the product came out (so be patient). Upon the first very small amount, I applied to my cheeks, gently massaging in as instructed. I could feel the prickly sensation of the spicules right away. I proceeded with my entire face, avoiding the eye area. I did take the product up into the temporal area. After feeling satisfied that I had massaged enough, I applied hyaluronic acid serum. Much to my surprise, this, too, caused the prickly sensation, making me feel as though my skin was reaping full benefits of the actives. Next, I applied Resveratol serum, followed by my moisturizer with peptides and other actives. All these subsequent skin care applications caused a mild warmth along with the same prickling. Here's the most amazing part, early the next morning while washing my hands, I noticed my skin had a glowy look. I had forgotten about the Exosome treatment until I looked closer. I put on my glasses and had my nose within a couple of inches of the mirror. I couldn't see a single pore. "Too good to be true," I thought, I moved to a another mirror with different lighting. Same outcome, I couldn't see a single pore! I had always heard that pores are pores and you can't really shrink them, especially with age. I am 62. With my own eyes, I see that my pores are no longer visible after just one treatment of Medicube Exosome Shot! I will continue to use this product, as I thought there was no hope for my large pores. It's my estimation that with long-term use, the active ingredients of my additional products will better reduce my wrinkles since those spinules are a game changer. Better than microneedling? Absolutely. I can't recommend this product enough.
D**D
Amazing results within a night?! So good
I wish I took a before photo because it would have been a great material for the review I’m leaving. My pores after hitting 40 have been much more visible resulting in uneven texture making it hard for foundation to stay put. I have been using PDRN 99% foam type from this same brand and it was an eye opener that my skin CAN take a turn for the better without botox and other means. I took a blind leap of hope with this one too. It worked wonders just within a night. I will be repurchasing and applying it as often as I’m allowed. It does feel prickly going on. It doesn’t hurt tho and it doesn’t keep feeling prickly once it dries down.
M**.
It's great but too much if you already have the rest of the medicube line.
If you have the 2000 and the 7500ppm., this 25000 will be too much and sadly pretty much useless. Although I love the heck out of this thing, I won't make a repurchase. I didn't see a remarkable change or difference. And that could be because I'm already using the daily one (2000ppm the light blue) and the 7500ppm. I can say if you are a beginner with any exosome shot or reedle shots, this is not beginner friendly. This will itself known with every layer of skincare you put on top of it. Item review: it does leave my skin feeling smoother than ever after using it at night. I still recommend it for anybody. Again if you are already using the pink and light blue one, you can skip this. You don't need a lot to cover your cheeks and nose and have a creamier consistency than the pink one.
C**N
Incredible results for acne scars – a must-have, but be mindful of the "tingle"!
I’ve been testing the medicube Exosome Shot Zero on my skin, and the results have been impressive. Redness Reduction: As you can see in my photos, the redness from my acne scar faded significantly in just four days, to the point where it’s barely noticeable. Targeted Use: I tested this specifically on the spot on my nose and left the spot above my lip untreated as a control. The difference is clear; this pen really works to calm redness. Application Tips & Precautions: Tingle Factor: Like the other "spicule" products, this one does tingle when you apply it. It can cause some itching and discomfort for a few minutes, though it usually feels fine by the next morning. If you have very sensitive skin, please use caution! Best Application Method: Because of the pen-like tip, I recommend applying it gently rather than rubbing it in with your hands. Use the tip to lightly massage and distribute the serum precisely where you need it. I find it works best as a targeted spot treatment. If you can handle the slight tingling sensation, this is an excellent tool for targeting specific skin concerns. Highly recommended!
W**D
I’ll give this five stars
I cannot say enough about this product. It is wonderful and has done some awesome goodness to my skin . I would use this again. I most definitely will purchase it again..
A**R
Packaging sucks
Terrible packaging on medicubes part. Had to take it apart and use a qtip to get product out. Product is great though, not very much for the cost especially considering packaging makes it unusable:/
T**H
Applicator good! Just ok
Personally I think the 7500 PPM works the same and has the same results and you don’t have as much tingly feeling with the 7500 does have a good applicator for more refined placement
M**E
Amazing product but…3rd UPDATE- MAKE SURE THE FONT IS IN BOLD AS SHOW IN MY PHOTOS!!!
UPDATE BELOW!!!!! And ANOTHER BELOW THAT! Photos are from 3rd review. LOOK CLOSELY at my Photos of the Bottles! 1 works, 1 DOES NOT! Might be expired?!!! Wow! This stuff is legit. I randomly found this on Amazon when looking for skin care products for my 14 year old daughter. I didn’t get this for her. I got it for myself. This product is too inexpensive and good to be true, only it is true! Tbh, I didn’t really research it before I bought it and used it. It was after I used it and how amazing it worked that I started looking more into the product. The 25,000 ppm dose. After just one time of using it, I was in shock as to how soft and smooth textured my skin was. The bottle doesn’t give the best directions about how much to apply so I just started squeezing a little and rubbing it in and a little more and more and more. I probably did about 7 full pumps. It absorbs and dries in just a minute or so. It doesn’t dry sticky or anything. It’s just like a standard nice serum. Now the big thing that all the hype or fear is about is the way it feels. Some say it’s torturous and feels like you are sticking your face in fiber glass or a cactus or something. I beg to differ. Well it does feel a little prickly for sure but it feels more like something that is getting deep in your skin. It feels like it’s working basically. What I noticed now after using this maybe 5 or 6 times over the last 3 weeks is that when you put it on you have 2 options. You can let it sit or you can put your night cream on. I let it sit for about 10 minutes and it does prickle but then I put my heavy night cream on. At first, the night cream makes it feel a little more prickly but then it really starts to just fade away. The longer you leave it sitting without heavy cream the pricklier it gets. I’m pretty tough, so I decided one time to put coconut oil on instead of night cream. Now that enhanced the prickles big time because it’s a carrier oil. But honestly that time was when I got the absolute most and best results from it. I don’t think you have to be afraid of this product at all and it’s prickles. I think you just need to know your limits. If you are sensitive and don’t like the feeling, just try it on your nose or in small areas. Noses are a little more tough because they are exposed to weather more so than other areas of the face, so they aren’t as sensitive. But my nose is actually one of the areas I found that it helped me the most. Cleaned my pores out completely and whether or not it shrunk them, I’m not sure but it sure looks like it to me. The very first thing I thought after seeing results was that something was wrong because this product should be going for probably $150 now $18 or $20. It’s too reasonably priced to not try and I’m almost positive if you can handle a little prickling feeling, you will be stoked on the results. I went and bought like 5 more of them because I was worried that the price would make a huge jump since it was so good. Oh and ready for a little bit of redness that goes away the next day or 2 days and longer pricklies if you use coconut oil but no peeling at all! After the research I realized how innovative and way far beyond the science being used in the USA. Totally worth every penny and feels like you are saving hundreds on micro needling because it has very similar results. I’m so done with micro needling now! Sorry to go off but seriously! I am just in total shock how well this stuff works and how amazing my skin looks. I will post a pic but not right now because I’m in a hurry and shouldn’t even be posting but I couldn’t help it!! My update using my second bottle of medicine Exosome Shot Zero 25,000 This one is not the same as the first one. I purchased it from Medicube on Amazon and absolutely nothing happened when I put it on my face! I’m really disappointed because that first one was absolutely amazing. This one has no prickly feeling. It feels like a face lotion or serum with no active ingredients. I have done absolutely nothing different from using the first container. So sadly now I am going to have to change my review from 5 stars 100% to 1 since there is no zero stars. What a bummer! I guess it’s the luck of the draw. I’m returning this one for sure and I hope that someone sees this part of the review and does some testing or something to make sure the potency is dispersed evenly among ther bottles! So so sad because I would have continued on to buy this forever pretty much. I have 4 more. I guess I will test them all and send back any and all that don’t work. Ahhh I’m so bummed! Another Update- putting bottles bought together side by side!!! Look at the photos! The one with the BOLD FONT on the right totally works! The other one does NOT! So BEWARE! Return before opening I guess if you get one that doesn’t have the bold font on the entire top section and a little lower where it says “Read instructions and caution before use.” And the word “Directions” lower down and the distribution info at bottom! Make sure it’s in bold!!!
N**É
Très bien
Très bien comme tous leurs produits. Par contre ma peau étant très habituée au peeling etc je trouve finalement que peu de différence avec le shoot 750 que j utilise 1 jour sur deux. Il ne pique pas plus que le 750 mais bon ma peau n est pas fragile. Medicube pour moi les meilleurs produits pour la routine beauté
こ**ち
普通に使えばそんな痛くない
どこよりも多い数字だけど最初全然痛くないじゃんと思った。 量増やしたらめっちゃ痛かった。 でもそれがたまらない。 量少ないからスペシャルケアだね。
C**.
increíble
Lo aplico en la noche y es muy bueno. Atenua las lineas de expresión, no hace milagros pero si, atenua bastante. Compré otro más solo en el 2do uso por si se acaba y luego no lo encuentro 🤣
A**E
Hält, was er verspricht.
Ich nutze ihn als Spot Treatment gegen Unterlagerungen und andere Unreinheiten. Für das komplette Gesicht sind der Azelain-Shot sowie der Zero Pore Shot (je in der 2000er sowie in der 7500er Version) meine Favoriten.
E**E
Great stuff
Oh this is the bees knees. It made my pores smaller. I love this spicule shot. It stings a bit but not in a bad way. I apply this first then finish with all other face creams and serum. I use it twice a week but in between I use 700 spicules shot. Since I’ve used it my face is as pure as I have ever seen it. I highly recommend it.
Trustpilot
2 weeks ago
2 weeks ago