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✨ Unlock your skin’s future with every micro-shot!
Medicube Exosome Shot Zero 2,000 PPM Spicule Facial Serum is a cutting-edge Korean skincare booster featuring 15 million patented Exosome shots and a unique micro-needle spicule design. Clinically proven to enhance absorption by 242%, it combines gentle exfoliation (AHA, BHA, PHA) with powerful hydration and skin barrier support, delivering visible improvements in texture, pore size, and radiance without irritation. Ideal for all skin types, this serum is a viral sensation for those seeking precise, next-level skin rejuvenation.







































| ASIN | B0D16L5F2M |
| Best Sellers Rank | #1,295 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #39 in Facial Serums |
| Brand | medicube |
| Brand Name | medicube |
| Customer Reviews | 4.5 out of 5 stars 3,770 Reviews |
| Item Form | Ampoule |
| Item Volume | 0.4 kg |
| Item Weight | 30 milligrams |
| Manufacturer | Medicube |
| Manufacturer Part Number | PMEKR14036 |
| Model Number | 8809981334928 |
| Number of Items | 1 |
| Product Benefits | Blemishes Treatment |
| Recommended Uses For Product | Dead Skin Cells,Skin Texture |
| Scent | Aloe |
| Scent Name | Aloe |
| Skin Tone | All |
| Skin Type | All, Combination, Dry, Oily, Oily Acne Prone, Sensitive |
| Special Ingredients | Alpha Hydroxy, Collagen, Minerals |
| Target Use Body Part | Face |
| Unit Count | 1.01 Fluid Ounces |
| Use for | Face |
J**E
Amazing Results in Just One Week! My Skin Has Never Looked Better!
I’ve been using the Medicube Exosome Shot Zero 2,000 PPM Serum consistently, and I’m honestly blown away by how quickly it started working. I’ve tried plenty of skincare products that promise smoother texture and smaller pores, but this is one of the few that actually delivered visible results! Within about one week, I noticed a real difference in my skin. The rough patches I usually struggle with felt softer, and my overall texture looked more refined. My skin started feeling smoother to the touch, and even my makeup applied better because the surface was more even. It wasn’t a dramatic overnight change, but it was a steady, noticeable improvement that kept getting better each day. The formula is lightweight and absorbs quickly without any sticky residue. I love that it combines exosomes with AHA, BHA, and PHA, because it gently exfoliates while supporting skin renewal, all without irritation. Even with the active ingredients, I didn’t experience redness or sensitivity, which is rare for me. I definitely feel the tingling or “needles” but it wasn’t bad at all After continued use, my skin looks healthier, clearer, and more balanced. The smoothness is the biggest difference, but I also feel like my pores look tighter and my complexion has a subtle glow that wasn’t there before. Overall, this serum has earned a permanent spot in my routine. If you’re dealing with uneven texture, dullness, or just want smoother, more refined skin, this product is absolutely worth trying. It’s one of the few skincare items where I can confidently say: I saw real results.
M**E
I was nervous to try, but it's so mild!
I was nervous to try this because of the spicules, since I’ve never used a spicule based product before. I chose the 2000 PPM Exosome Shot to start on the gentler side, and I was pleasantly surprised by how mild it actually feels on the skin. I use this once a week after cleansing (about two pumps), gently pat it in, and then follow with my nighttime moisturizer. There is a very slight pokey sensation on application, but it’s not painful or irritating- just noticeable enough to know it’s there. By morning, my skin looks noticeably smoother, more refined, and almost glass-like. I have reactive, eczema-prone skin, so I’m usually very cautious with exfoliating products and anything containing acids. Despite the AHA + BHA + PHA blend and spicules, I have not experienced dryness, itching, or sensitivity with weekly use. The exfoliation feels effective, but not harsh or barrier stripping. I also like that the formula includes niacinamide and soothing components alongside the exfoliants, which likely help balance the overall results. The texture is lightweight, spreads easily, and layers well with other skincare without pilling or being sticky. Overall, this is a great entry level spicule serum if you’re curious but hesitant. It delivers smoother, more refined looking skin texture without the aggressive irritation I anticipated. I will likely continue with the 2000 PPM for maintenance, and may consider trying the higher strength once my skin fully acclimates.
A**E
Yes this product does work very well with an already established skincare routine.
Ima be honest, I was skeptical on how well this product works after hearing it all over tiki tok but they are definitely onto something. I got the exosome 2000 yesterday and used it the same night. I admit, yes it does itch and sting but its tolerable and went away after like 30 - 45 mins of using. It didnt make my skin red, which was surprising. My current routine is: Pm only; - anua oil cleanser - anua deep pore cleanser - anua 70 toner - (now) medicue one day exosome shot 2000 - (now) corsx vitamin c 23 - corsx snail mucin essence - Neutrogena firm moisturizer or anua daily lotion [ i like to switch between the two ] Im 31 years old, my skin is textured with dark spots, dull and I have a chubby face with few fine lines, scars and huge pores on the apples of my cheeks and some on my nose. I get millia under my eyes/ on the top of my cheek sometimes. Its not too close to the thin skin under my eyes. Today ( the next morning) I noticed my pore are visibly smaller. Wow really?! Yes really! even after 1 use. It's like an exfoliant that my skin needed. (Paula's choice bha, aha exfoliating toner sucks and did not work for me). I noticed my skin was softer and the Milia looks like it opened up and the ball inside is ready to fall out. This product will become part of my skincare routine for sure! I will repurchase and highly suggest this product.
Z**O
WORKSS! But leaves pieces of silver paint all over hands and face... 💔
I love this SO MUCHHHH it makes my skin feel so soft and plump and helps fade my acne scars more than anythingg atm-- especially paired with vitamin c!!! 😊 BUT BRO AFTER USING THIS FOR LIKE 3 months I think??? THE SILVER PAINT STARTED CHIPPING OFF AND GETS ALLL over my hands before I get to even use it... Like look at it vro...💔 Then I'm rubbing pieces of silver all over my face, into my skin etc. and it sticks like glitter... It's the WORST bro it's soso so annoying plz this part of it is so unnecessary plzz js make it white without the silver coating 💔 Love u... Anyway the product itself works really nicely!! I use it every night (mostly) followed by a moisturiser and definitely works out. 😊 Did exactly what advertised for chat 🗣 Feels and looks more plump, softer, less texture and lightens scarring!!! #awesome It stings a lil but it feels nice idk feels fancy and didn't cause any trouble with my skin barrier, just stung like exfoliation but less ykyk?! I have dry/combination skin and not prone to acne and 17f🙏 Def worth the moneyy u should snag it if u want to scrub off all the silver 🥰 JOKE but unironically it's goated ok bye
M**A
Great Addition to My Skincare Routine!
I've been very impressed with this serum. It absorbs quickly, feels lightweight on the skin, and layers well with the rest of my skincare products. After consistent use, my skin feels smoother, more hydrated, and appears brighter and healthier. The formula provides a gentle boost without feeling heavy or sticky. A little goes a long way, making the bottle last longer than expected. Overall, it's a high-quality serum that delivers noticeable results and is well worth trying. ✨😊⭐💧
R**E
It literally Works
Has transformed my skin. I had large poors around my nose and under eyes. After using this product for about a month it have seen so much of a difference! My skin is smooth and pore less. Not going to lie it does tingle but your skin gets used to it. I was using it 2-3 times a week and its been a staple for me in my routine.
A**R
Slightly irritating, not sure about the spicules over long term
I like medicube serums and skincare products and I have tried medicube toner pads which I liked and a moisturizer which I also liked. This is my first time trying spicules so I went easy and I did a test spot on my inner arm. I did not have a reaction, but my arm felt hyper sensitive for a few hours. This absorbed quickly, stayed a little tacky which I wasn’t too excited about but it’s doable if it works. I patch tested on my chin and I did not get a reaction. I am going to use this on my chest and for spot treatment because I am still a little concerned about teeny tiny particles going into my skin…. Look what happened with hyaluronic acid filler that everyone though was a great skin plumper—- I’m going to go easy with this..
P**E
Great stuff
First, I want to share that I’m fairly knowledgeable about skincare actives and have built solid routines in the past. A few years ago, due to significant health issues, I stopped prioritizing skincare altogether. Now at 55, I’ve decided it’s time to care for my skin again. I purchased Medicube One Day Exosome Shot 2000 on a whim after reading great reviews, mainly to address dullness and enlarged pores. What initially caught my attention was the delivery system—it seemed thoughtfully designed and potentially very effective for resurfacing and product absorption. Although my skin has historically tolerated acids well, it had been quite some time since I used anything resurfacing, so I started with the 2000 PPM formula. I applied it using both rubbing and patting techniques, and experienced no burning or tingling, which was reassuring. After purchasing, I took a more analytical approach to rebuilding my routine and evaluated all of my current products together for long-term skin health (using AI). This product made the “keep” list. The recommendation was to use it strategically—about once per month—as a targeted treatment to stimulate cell turnover and enhance absorption of select follow-up products. I even considered returning it, but after reviewing how it fit into a multi-year skincare plan, it still stood out as beneficial. Rather than being an everyday product, it works best as a periodic reset for dull or congested skin. So far, I’m impressed with how thoughtfully this fits into a structured routine, and I appreciate that it delivers resurfacing benefits without irritation. For anyone rebuilding their skincare regimen or looking for a targeted monthly treatment to improve texture and radiance, this is definitely worth considering.
N**E
Mega Gut !
Ja es ist ein wenig als wenn man sich mit Brennnesseln abreiben aber es funktioniert nach der ersten Anwendung. Meine Poren waren deutlich kleiner. Meine Haut hat auch keine Reizungen gehabt, obwohl ich sehr Empfindlich bin. Würde es wieder kaufen.
م**ا
ابر نضاره في منزلك
جميل جدا كانك تضربين ابر نضاره جميل جدا
H**T
Top
Top
D**.
Unbelievable
I swear for the price and the effect it shows 10/10. Tbh I didn’t expect much from this all I know it’s that it kinda hurts and it replicates microblading but at home version so I got it. But I swear I’ve been using it as a night time routine and my dark spots is becoming lighter and lighter! I had this a HUGE dark pigmented spot on my cheek due to a pimple (literally every pimple I get leave a dark mark on my face it’s so annoying) anyways it’s now fading!!!!!! And what I got this product 2 weeks ago?? Fabulous. Definitely give it a go
J**A
Pica un poco en la piel
Tengo poco usándolo,pero sí pica cuando lo uso. Espero cumpla su función
Trustpilot
1 month ago
2 weeks ago