Is it possible to use two sets of outputs - as in run the XLR outputs to the house PA and run the line outs to a keyboard amp so band can monitor?

Yes, the input signal, regardless of connector used, is present on all outputs. http://artproaudio.com/downloads/specsheets/ss_dti.pdf

does it have a ground "lift" option, switchable?

No "BUT" all outputs are ground isolated from the chassis so a "lift" switch is not necessary when using this.

I want to use my studio monitors with my Macbook Pro. What cable do I need to use to plug this into my laptop?

Hi Jason,I would use an 1/8" to XLR Male Y cable like this:http://www.amazon.com/Hosa-CYX-403M-Stereo-Breakout-Cable/dp/B000068OEP/ref=sr_1_9?m=A3QYKZ7LXW9O3&s=merchant-items&ie=UTF8&qid=1448889739&sr=1-9&keywords=hosa+1%2F8+to+xlrIf this was helpful, please consider purchasing from us. We have them both in stock and ready to ship. - Pixel Pro Audio

My single coil pups are picking up interference (nearby laptop, etc) and causing my amp to hum and click; higher gain makes it worse. will this work?

You need a ground loop isolator. Some are as cheap as $20

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Description

🎧 Silence the noise, amplify your clarity.

BUILT TO LAST - Durable anodized aluminum housing ensures reliable performance on the road or in-studio.
PLUG PLAY SIMPLICITY - No power needed—just connect and enjoy interference-free sound instantly.
ZERO NOISE PURE SOUND - Passive transformers isolate and eliminate hum for crystal-clear audio.
UNIVERSAL COMPATIBILITY - Multiple input/output options (1/4", RCA, XLR) fit any pro audio setup seamlessly.
PRO GRADE SIGNAL INTEGRITY - High-quality transformers maintain flat frequency response and unity gain.

The Art Pro Audio DTI Transformer/Isolator is a passive audio interface designed to eliminate ground loop hum by isolating signal grounds using high-performance transformers. Featuring versatile 1/4", RCA, and XLR inputs and outputs, it fits effortlessly into any professional or home audio system. Housed in a rugged anodized aluminum case, the DTI delivers clean, neutral sound with a wide frequency response and requires no power, making it an essential tool for live sound, studio, and installation applications.

Specifications

Manufacturer	ART APPLIED RESEARCH AND TECHNOLOGY
Part Number	DTI
Product Dimensions	27.94 x 7.62 x 17.78 cm; 340 g
Item model number	DTI
Colour	Black
Style	Eliminator
Voltage	240 Volts
Item Package Quantity	1
Special Features	The ART DTI is a high-quality, totally passive solution box intended to eliminate noise (or "hum") in sound systems that is caused by ground loop effects. The DTIâ¢ offers a variety of connection types, has a high performance audio transformer, will not degrade the audio signal, and does not require power. The ARTcessories DTIâ¢ is a high quality, rugged and affordable enhancement to any professional studio, home recording, and touring or installed live performance sound system.
Batteries included?	No
Batteries Required?	No
Item Weight	340 g

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