Since 1981, several hundred studies have been published on DHEA which has various benefits, including immunomodulatory properties as well as positive effects on mood, quality of life, and body composition. It has been proposed that restoring the circulating levels of DHEA to those found in young people may improve well-being and sexual function. In a recent randomized, double-blind, placebo-controlled study, ten months of DHEA replacement therapy has the beneficial effect of enhancing the increases in muscle mass and strength with the addition of resistance exercise in elderly individuals.4 The studies of DHEA therapy in women with adrenal insufficiency also suggest beneficial effects on well-being, mood, and sexuality.5 DHEA could be of benefit to the normal aging brain.6-8 Some studies have reported DHEA may improve mood and alleviate melancholy.9 In addition, recent studies in vitro have shown that DHEA has the capacity to improve endothelial function by increasing nitric oxide (NO) synthesis.10.Ideally, DHEA replacement therapy should begin with blood testing to establish a base range. Since almost everyone over age 35 40 has lower than optimal levels of DHEA, most people begin supplementation and test their blood DHEA levels later to make sure they are taking the proper dose.
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