Kaempferol

Name: Kaempferol
Brand: Tocris
Availability: OutOfStock

Product ID: 101508170

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Description

Citations: 1
Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Other Ion Pump/Transporter Activators
CAS: 520-18-3
Molecular Weight: 286.24

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporterSize: 50 mgChemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-oneCAS No: 520-18-3Molecular Weight: 286.24Activity: Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.Citations: 1

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