---
product_id: 74178811
title: "E45 Itch Relief Cream 50 g – Anti Itch Cream for Skin Irritation – Non-Greasy E45 Cream to Relieve Itching – Eczema Dermatitis Cream – Instantly Soothes and Calms Skin - E45 for Itching"
brand: "e45"
price: "R216"
currency: ZAR
in_stock: true
reviews_count: 9
category: "E45"
url: https://www.desertcart.co.za/products/74178811-e45-itch-relief-cream-50-g-anti-itch-cream-skin
store_origin: ZA
region: South Africa
---

# 3% Lauromacrogols for fast itch relief 5% Urea for deep hydration Non-greasy, lightweight formula E45 Itch Relief Cream 50 g – Anti Itch Cream for Skin Irritation – Non-Greasy E45 Cream to Relieve Itching – Eczema Dermatitis Cream – Instantly Soothes and Calms Skin - E45 for Itching

**Brand:** e45
**Price:** R216
**Availability:** ✅ In Stock

## Summary

> ✨ Soothe, hydrate, and conquer dry skin discomfort like a pro!

## Quick Answers

- **What is this?** E45 Itch Relief Cream 50 g – Anti Itch Cream for Skin Irritation – Non-Greasy E45 Cream to Relieve Itching – Eczema Dermatitis Cream – Instantly Soothes and Calms Skin - E45 for Itching by e45
- **How much does it cost?** R216 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.co.za](https://www.desertcart.co.za/products/74178811-e45-itch-relief-cream-50-g-anti-itch-cream-skin)

## Best For

- e45 enthusiasts

## Why This Product

- Trusted e45 brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Dual-Action Relief:** Targets itching and irritation caused by eczema, dermatitis, and dry skin for all-day comfort.
- • **Everyday Essential:** Compact 50g tube perfect for your bedside or bathroom—never miss a soothing moment.
- • **Legacy of Expertise:** 60 years of skincare innovation trusted by millions for effective dry skin treatment.
- • **Hydration Powerhouse:** Formulated with 5% urea to lock in moisture and restore your skin’s natural barrier.
- • **Dermatologist-Tested Trust:** Clinically proven and fragrance-free, safe for sensitive skin on face, hands, and body.

## Overview

E45 Itch Relief Cream is a clinically tested, non-greasy formula combining 5% urea and 3% lauromacrogols to instantly soothe itching and skin irritation caused by eczema, dermatitis, and dry skin. Trusted for over 60 years, this fragrance-free cream hydrates deeply while calming sensitive skin, making it an essential daily skincare solution for professionals seeking effective relief and skin comfort.

## Description

Product Description E45 ITCH RELIEF CREAM Ingredients E45 Itch Relief Cream is a white cream containing Lauromacrogols 3.0%w/w and Urea 5.0% w/w as active ingredients and also Dimeticone, Phenyl Dimeticone, Liquid Paraffin, Cetyl Palmitate, Stearic Palmitic Acid, Octyldodecanol, Glycerol, Polysorbate, Carbomer, Trometamol, Benzyl Alcohol, Purified Water P.when('A').execute(function(A) { A.on('a:expander:toggle_description:toggle:collapse', function(data) { window.scroll(0, data.expander.$expander[0].offsetTop-100); }); }); Safety Warning May cause allergic reactions (possibly delayed), such as local skin reaction. Do not use on broken or inflamed skin. Keep out of the sight and reach of children Manufacturer Contact Information MA holder: Crookes Healthcare Ltd, NG2 3AA, UK. Manufacturer: Reckitt Benckiser Healthcare (UK) Ltd, HU8 7DS. See more

Review: Excellent product for itchy skin - Excellent, works very well on eczema
Review: Good product. - Very effective. Just the right size to keep in bedroom and/or bathroom

## Features

- TREAT ITCHING AND SKIN IRRITATION – E45 Itch Relief Cream is a dual action treatment for skin irritation and itching caused by dry skin conditions, eczema, dermatitis, pruritus, and scaling skin conditions.
- MOISTURISING AND ANTI-ITCH INGREDIENTS – E45 Itch Relief Cream is formulated with urea which helps your skin to retain moisturise and keeps it hydrated. Our cream is also dermatologically tested and scientifically proven to provide effective skin relief.
- HOW TO USE – Apply to the affected skin area twice daily for effective relief for itching and skin irritation. Our cream is perfume free can be used in all skin areas such as the body, face, and hands.
- QUALITY SKINCARE EVERY DAY – For 60 years, E45 has been a skincare expert in dry and itchy skin and treatment for eczema, psoriasis, ichthyosis and other dry skin conditions. It has proven dermatological expertise dedicated to vulnerable dry skin.
- HISTORY OF E45 – We released our E45 Cream in 1952 after a customer request for a product that would soothe and protect the skin. In 1963 our cream was introduced to pharmacy and retail in 1980.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B01BKO8B4G |
| ASIN  | B01BKO8B4G |
| Best Sellers Rank | 1,636 in Health & Personal Care ( See Top 100 in Health & Personal Care ) 8 in Itching & Rash Treatments 11 in Skin Condition Remedies |
| Brand | E45 |
| Country of origin | United Kingdom |
| Customer Reviews | 4.5 4.5 out of 5 stars (1,714) |
| Customer reviews | 4.5 4.5 out of 5 stars (1,714) |
| Date First Available | 8 Feb. 2016 |
| Format | Cream |
| Item model number  | 100694329 |
| Manufacturer  | E45 |
| Manufacturer contact | MA holder: Crookes Healthcare Ltd, NG2 3AA, UK. Manufacturer: Reckitt Benckiser Healthcare (UK) Ltd, HU8 7DS. |
| Product Dimensions  | 3.8 x 4.2 x 14.2 cm; 60 g |
| Storage Instructions | Store below 25°c. |
| Units | 50.0 Grams |
| Weight | 50 g |

## Images

![E45 Itch Relief Cream 50 g – Anti Itch Cream for Skin Irritation – Non-Greasy E45 Cream to Relieve Itching – Eczema Dermatitis Cream – Instantly Soothes and Calms Skin - E45 for Itching - Image 1](https://m.media-amazon.com/images/I/51SALsc4EwL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: Is this cream anti-fungal?**
A: I do not believe this cream is antifungal but it does work on reducing itchiness on unbroken skin

## Customer Reviews

### ⭐⭐⭐⭐⭐ Excellent product for itchy skin
*by P***D on 26 October 2025*

Excellent, works very well on eczema

### ⭐⭐⭐⭐⭐ Good product.
*by M***S on 31 December 2025*

Very effective. Just the right size to keep in bedroom and/or bathroom

### ⭐⭐⭐⭐ Soothing.
*by M***N on 22 August 2025*

Works quite well. It is a relief when I use it.

## Frequently Bought Together

- E45 Itch Relief Cream 50 g – Anti Itch Cream for Skin Irritation – Non-Greasy E45 Cream to Relieve Itching – Eczema Dermatitis Cream – Instantly Soothes and Calms Skin - E45 for Itching
- Eurax Itch Relief Cream, Hydrating Relief from Itchy & Irritated Skin, Alleviates Itching from Rashes, Eczema, Dermatitis & Chickenpox, Dermatologist Recommended, Contains Crotamiton, 1 x 30g
- Pinewoods Fast Acting Hydrocortisone Cream 1% w/w Bite and Sting Cream, Mosquito and Bee Sting Treatment, Itchy Skin and Redness Solution, 3 x 10g Tubes for Eczema and Irritation

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*Product available on Desertcart South Africa*
*Store origin: ZA*
*Last updated: 2026-03-06*