---
product_id: 4114431
title: "FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments"
brand: "frontline"
price: "R1299"
currency: ZAR
in_stock: true
reviews_count: 10
category: "Frontline"
url: https://www.desertcart.co.za/products/4114431-frontline-plus-flea-and-tick-treatment-for-large-dogs-up
store_origin: ZA
region: South Africa
---

# 30-day continuous protection Waterproof formula Kills fleas, eggs, larvae & ticks FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

**Brand:** frontline
**Price:** R1299
**Availability:** ✅ In Stock

## Summary

> 🐾 Stay ahead of pests, keep your best friend itch-free and unstoppable!

## Quick Answers

- **What is this?** FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments by frontline
- **How much does it cost?** R1299 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.co.za](https://www.desertcart.co.za/products/4114431-frontline-plus-flea-and-tick-treatment-for-large-dogs-up)

## Best For

- frontline enthusiasts

## Why This Product

- Trusted frontline brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Month-Long Defense:** One easy monthly dose shields your dog from fleas & ticks for a full 30 days, so you never miss a beat.
- • **Waterproof & Active:** Water-resistant formula stays effective even after baths or outdoor adventures—no downtime for your pup.
- • **Trusted for 20+ Years:** Veteran pet owners swear by FRONTLINE’s proven track record of reliable, fast-acting parasite control.
- • **Effortless Application:** Single spot topical treatment that spreads naturally through your dog’s skin oils—no mess, no fuss.
- • **Complete Life Cycle Kill:** Targets adult fleas, eggs, larvae, and ticks, breaking the infestation cycle before it starts.

## Overview

FRONTLINE Plus for Large Dogs (45-88 lbs) delivers fast, waterproof flea and tick protection with a scientifically proven formula that kills fleas, eggs, larvae, and ticks for 30 days. Trusted by pet owners for over two decades, this easy-to-apply topical treatment ensures your dog stays comfortable and protected, even during wet conditions. Ideal for dogs 8 weeks and older, it breaks the flea life cycle to prevent reinfestation and supports year-round parasite control with convenient subscription options.

## Description

Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.

Review: Finally found something that actually works! - After trying at least four different flea treatments that barely made a dent, I'm so relieved to have found these drops. They actually work - and work fast. We have two dogs who love being outside, and fleas have been an ongoing battle, especially during the warmer months. Within 24 hours of applying these drops, I noticed a huge difference. The scratching stopped, and when I checked them over, the fleas were gone. It's been several weeks now and still no sign of them coming back. Application is easy - just part the fur at the back of the neck and squeeze the tube. My dogs don't seem bothered by it at all, and it dries quickly so they can go about their day. The protection lasts the full month as advertised, which is more than I can say for some of the other brands we've tried. I've set up a subscription so I never run out because I'm not going back to the constant scratching and discomfort my pups were dealing with before. If you've been struggling to find an effective flea treatment, I highly recommend giving these a try. They've been a game-changer for us. Worth every penny for the peace of mind and happy, comfortable dogs!
Review: Frontline Defense - Works very well. Buying a lesser off brand or generic brand isn't worth it. Frontline is the best. Caution: make sure to buy the proper dose for your dog according to their weight. It is better &, safer to under dose and underestimate than to ever estimate. If your dog as a tick infestation you will have to remove the dead ticks with a tick removal device & bathe the dog afterwards. Their product is worth every penny & more. Don't waste your money on Genetic substitutions in in this case. Keeps dog & companion animals happy & healthy

## Features

- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0002J1FOE |
| ASIN  | B0002J1FOE |
| Age Range Description | All Life Stages |
| Best Sellers Rank | #376 in Pet Supplies ( See Top 100 in Pet Supplies ) #3 in Dog Flea Drops |
| Brand Name | Frontline |
| Breed Recommendation | Large Dog, 45 to 88 pounds |
| Care Instructions | Do not use on kittens under 8 weeks of age or 1.5 lbs |
| Color | Purple Box |
| Country of Origin | France |
| Customer Reviews | 4.4 4.4 out of 5 stars (49,583) |
| Date First Available | September 2, 2004 |
| Date First Available  | September 2, 2004 |
| Department | Insect Control |
| Department  | Insect Control |
| Directions | Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze… |
| Included Components | Package includes 3 applicators |
| Is Discontinued By Manufacturer  | No |
| Item Dimensions LxWxH | 5.75 x 0.75 x 4.5 inches |
| Item Package Dimensions L x W x H | 5.83 x 4.37 x 0.75 inches |
| Item Weight | 0.04 Pounds |
| Item model number | 72219 |
| Item model number  | 72219 |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Manufacturer  | Boehringer Ingelheim Animal Health |
| Manufacturer recommended age  | 1 month and up |
| Material | Fipronil, S-Methoprene |
| Model Name | FRONTLINE Plus for Dogs Medium Dog (23-44 pounds) Flea and Tick Treatment, 3 Doses |
| Number of Items | 1 |
| Product Dimensions  | 5.75 x 0.75 x 4.5 inches; 0.64 ounces |
| Size | 3 Count |
| Specific Uses for Product | Parasites |
| Style | Large Dog (45-88 lbs.) |
| Target Audience Keyword | ( reptiles | amphibians ), dogs, dogs|( reptiles | amphibians ) |
| Warranty Description | only for dog |

## Product Details

- **Active Ingredients:** fipronil and (S)-methoprene
- **Age Range (Description):** All Life Stages
- **Allergen Information:** Abalone Free
- **Brand:** Frontline
- **Dog Breed Size:** Large
- **Item Form:** Liquid
- **Item Volume:** 339 Milliliters
- **Item Weight:** 0.04 Pounds
- **Scent:** Unscented
- **UPC:** 350604287209 666672366389

## Images

![FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments - Image 1](https://m.media-amazon.com/images/I/71cWyt6fBNL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: I've been using Frontline Plus for years, but lately it seems to be not as effective as it used to be. Has anyone noticed the same results ?**
A: Yes! After trying multiple flea & tick medication, my dog wasn’t getting any better...took her to the vet & she stated that the over the counter flea & tick medication isn’t effective since it’s been on the market for some time, the fleas have evolved & aren’t responding to the meds. Plus she said this season has been the worst so that doesn’t help either!!! Take them to the vet, my dog now is flea/tick free

**Q: "hola buenas tardes, compre este producto pero no veo o no sale la fecha de caducidad ( vencimiento ) del producto "**
A: Siempre que lo mantenga a temperatura ambiente y sellado en su empaque original, FRONTLINE Plus permanecerá listo para la batalla!

**Q: Can I give her a bath**
A: "It is OK to bathe your pet before using FRONTLINE, but the coat should be completely dry prior to application. In the 48 hours immediately after treatment, do not bathe, shampoo or let your dog go swimming." (FRONTLINE webste)
   This medication works systemically after being absorbed through the skin. Insufficient dosing will lead to product failure.

**Q: effectiveness**
A: Ive never had a flea problem with frontline, but for ticks they would attach to the dog before it died. 
So i switched to the seresto 8 month collar. The 1st one i used worked great no issues. The 2nd one 
(8months later) had the same date as the first one. I dont know if that was an issue but the collar stopped working 
after 5 months and we ended up with fleas. First time that we ever had fleas. So i am going back to frontline. 
My concerns are the date on package and where its coming from.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Finally found something that actually works!
*by R***Z on February 9, 2026*

After trying at least four different flea treatments that barely made a dent, I'm so relieved to have found these drops. They actually work - and work fast. We have two dogs who love being outside, and fleas have been an ongoing battle, especially during the warmer months. Within 24 hours of applying these drops, I noticed a huge difference. The scratching stopped, and when I checked them over, the fleas were gone. It's been several weeks now and still no sign of them coming back. Application is easy - just part the fur at the back of the neck and squeeze the tube. My dogs don't seem bothered by it at all, and it dries quickly so they can go about their day. The protection lasts the full month as advertised, which is more than I can say for some of the other brands we've tried. I've set up a subscription so I never run out because I'm not going back to the constant scratching and discomfort my pups were dealing with before. If you've been struggling to find an effective flea treatment, I highly recommend giving these a try. They've been a game-changer for us. Worth every penny for the peace of mind and happy, comfortable dogs!

### ⭐⭐⭐⭐⭐ Frontline Defense
*by A***D on February 21, 2026*

Works very well. Buying a lesser off brand or generic brand isn't worth it. Frontline is the best. Caution: make sure to buy the proper dose for your dog according to their weight. It is better &, safer to under dose and underestimate than to ever estimate. If your dog as a tick infestation you will have to remove the dead ticks with a tick removal device & bathe the dog afterwards. Their product is worth every penny & more. Don't waste your money on Genetic substitutions in in this case. Keeps dog & companion animals happy & healthy

### ⭐⭐⭐⭐⭐ Frontline plus flea and tick treatment for dogs
*by L***N on February 15, 2026*

This works great! I have used it for years. I have tried other brands but they don't compare. Easy to use and does not have a horrible smell. Much better than flea and tick collars too

## Frequently Bought Together

- Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
- Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments
- Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

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*Product available on Desertcart South Africa*
*Store origin: ZA*
*Last updated: 2026-02-26*