--- product_id: 254644750 title: "K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary)" brand: "k9 advantix" price: "R3275" currency: ZAR in_stock: true category: "K9 Advantix" url: https://www.desertcart.co.za/products/254644750-k9-advantix-ii-large-dog-vet-recommended-flea-tick-mosquito store_origin: ZA region: South Africa --- # For dogs 21-55 lbs Waterproof after 24 hours Kills fleas in 12 hours K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary) **Brand:** k9 advantix **Price:** R3275 **Availability:** ✅ In Stock ## Summary > 🐾 Stay ahead of pests—because your big buddy deserves the best! ## Quick Answers - **What is this?** K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary) by k9 advantix - **How much does it cost?** R3275 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.co.za](https://www.desertcart.co.za/products/254644750-k9-advantix-ii-large-dog-vet-recommended-flea-tick-mosquito) ## Best For - k9 advantix enthusiasts ## Why This Product - Trusted k9 advantix brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Multi-Pest Defense:** Vet-recommended formula repels & kills fleas, ticks, mosquitoes, biting flies, and lice on contact - • **Waterproof Protection:** Fragrance-free and waterproof after just 24 hours for worry-free outdoor adventures - • **Effortless Application:** Topical spot-on treatment goes on in seconds—no pills, no collars, no hassle - • **No Prescription Needed:** Convenient OTC availability means your dog stays protected without extra vet visits - • **Rapid Flea Elimination:** Kills fleas within 12 hours to stop infestations fast ## Overview K9 Advantix II Large Dog is a vet-recommended, topical flea, tick, mosquito, biting fly, and lice treatment for dogs 21-55 lbs. It kills fleas within 12 hours and repels pests on contact, preventing infestations without the need for a prescription. Waterproof after 24 hours and fragrance-free, it offers fast, easy, and effective monthly protection to keep your dog comfortable and healthy. ## Description K9 Advantix II Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they can’t lay eggs and they don’t have to bite your dog to die. Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia. That’s why K9 Advantix II Large Dog topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21-55 lbs. to use K9 Advantix II Large Dog. For the ultimate convenience in care, K9 Advantix II is available over the counter – no prescription needed. And, you can stock up with 2-dose, 4-dose and 6-dose packs so you never miss a monthly treatment. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park. K9 Advantix II Large Dog is a trademark of Elanco or its affiliates. ## Features - K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice - Kills fleas within 12 hours of application - Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die - Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours - No prescription needed ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B00N7DEBN4 | | Active Ingredients | Imidacloprid, Permethrin, Pyriproxyfen | | Age Range Description | 7 weeks and older | | Allergen Information | Allergen-Free | | Best Sellers Rank | #13,076 in Pet Supplies ( See Top 100 in Pet Supplies ) #22 in Dog Flea Drops | | Brand Name | K9 Advantix | | Customer Reviews | 4.4 4.4 out of 5 stars (25,754) | | Dog Breed Size | Large | | Item Form | Topical | | Item Type Name | Topical | | Item Weight | 9 g | | Manufacturer | K9 Advantix | | Manufacturer Part Number | 86314940 | | Model Number | 86314940 | | Pet Type | Dog | | Scent Name | Unscented | | Target Species | Dog | | UPC | 724089060716 | | Unit Count | 2 Count | | Volume | 5 Milliliters | ## Product Details - **Active Ingredients:** Imidacloprid, Permethrin, Pyriproxyfen - **Brand:** K9 Advantix - **Item form:** Topical - **Item weight:** 0.02 Pounds - **Scent:** Unscented ## Images ![K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary) - Image 1](https://m.media-amazon.com/images/I/71TEm2OCbGL.jpg) ## Available Options This product comes in different **Size** options. ## Frequently Bought Together - K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply (Packaging may vary) - K9 Advantix II XL Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs Over 55 lbs. | 2-Mo Supply - K9 Advantix II Medium Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11-20 lbs. | 2-Mo Supply --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.co.za/products/254644750-k9-advantix-ii-large-dog-vet-recommended-flea-tick-mosquito](https://www.desertcart.co.za/products/254644750-k9-advantix-ii-large-dog-vet-recommended-flea-tick-mosquito) --- *Product available on Desertcart South Africa* *Store origin: ZA* *Last updated: 2026-10-11*