---
product_id: 253630147
title: "Derma Purifying System 2 Cleanser Shampoo (Natural Hair, Progressed Thinning) 500ml/16.9oz"
brand: "nioxin"
price: "R1018"
currency: ZAR
in_stock: true
reviews_count: 5
category: "Nioxin"
url: https://www.desertcart.co.za/products/253630147-derma-purifying-system-2-cleanser-shampoo-natural-hair-progressed-thinning
store_origin: ZA
region: South Africa
---

# 16x Stylist Choice Winner 500ml professional scalp cleanser Activ-Renewal tech removes sebum & residue Derma Purifying System 2 Cleanser Shampoo (Natural Hair, Progressed Thinning) 500ml/16.9oz

**Brand:** nioxin
**Price:** R1018
**Availability:** ✅ In Stock

## Summary

> ✨ Unlock your scalp’s potential with every wash!

## Quick Answers

- **What is this?** Derma Purifying System 2 Cleanser Shampoo (Natural Hair, Progressed Thinning) 500ml/16.9oz by nioxin
- **How much does it cost?** R1018 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.co.za](https://www.desertcart.co.za/products/253630147-derma-purifying-system-2-cleanser-shampoo-natural-hair-progressed-thinning)

## Best For

- nioxin enthusiasts

## Why This Product

- Trusted nioxin brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Award-Winning Formula:** Trusted by stylists for 16 consecutive years
- • **Thicker, Fuller Hair Boost:** Visibly amplifies hair density and volume
- • **Complete 3-Step System Ready:** Preps hair for maximum thickening treatment results
- • **Deep Derma Purifying Cleanse:** Eliminates buildup for a fresh, healthy scalp
- • **Proven Activ-Renewal Technology:** Targets sebum, fatty acids & environmental residue

## Overview

Nioxin Derma Purifying System 2 Cleanser Shampoo is a professional-grade 500ml formula designed specifically for natural hair experiencing progressed thinning. Featuring Activ-Renewal technology, it deeply cleanses the scalp by removing sebum, fatty acids, and environmental residues, promoting thicker, fuller-looking hair. Celebrated as a 16-time Behind the Chair Stylist Choice Winner, this shampoo is the essential first step in Nioxin’s three-part hair thickening regimen, ideal for daily use and optimized when paired with the System 2 Conditioner and Scalp Treatment.

## Description

Prepare hair and scalp for a complete hair thickening treatment with Nioxin’s three part System 2 Cleanser for Natural Hair with Progressed Thinning. This professional hair product’s Activ-Renewal technology helps remove sebum, fatty acids and other environmental residue from the scalp and hair. Nioxin’s Derma-purifying shampoo deeply cleanses the scalp and provides thicker, fuller-looking hair. Nioxin’s Shampoo cleanser is the first step of a three part Nioxin regimen, designed to strengthen the hair and amplify hair structure. Professional hair and scalp cleanser shampoo for natural hair with progressed thinningDerma Purifying Shampoo deeply cleanses the scalp and provides thicker, fuller looking hairActiv renewal technology helps remove sebum, fatty acids and other environmental residue from the scalp and hairPrepare hair and scalp for a complete hair thickening treatment starting with shampoo cleanserNioxin shampoo cleanser is the first step of a three part Nioxin regimen, designed to strengthen the hair and amplify hair structureAward: Behind the Chair Stylist Choice Winner, Favorite Thinning Haircare, 16 consecutive yearsFor Best Results: Apply to wet hair, gently massage into scalp and hair, lather 1 minute, rinse thoroughly, use dailyUse in combination with Nioxin System 2 Scalp Therapy Conditioner plus Scalp and Hair TreatmentEnroll in Subscribe and Save to ensure you never run out.

Review: Controls hair dandruff, fungus really well. Also works for hair fall. Smells good.👍
Review: El shampoo me ha caído muy bien para mi cuero cabelludo sensible, graso, me lo ha limpiado sin irritarlo y me ha ayudado a que me salga más.

## Features

- Professional hair and scalp cleanser shampoo for natural hair with progressed thinning . Award: Behind the Chair Stylist Choice Winner Favorite Thinning Haircare, 16 consecutive years
- Derma purifying shampoo deeply cleanses the scalp and provides thicker, fuller looking hair
- Activ renewal technology helps remove sebum, fatty acids and other environmental residue from the scalp and hair
- Prepare hair and scalp for a complete hair thickening treatment with nioxin's three part system 2 cleanser for natural hair with progressed thinning
- Nioxin shampoo cleanser is the first step of a three part Nioxin regimen, designed to strengthen the hair and amplify hair structure.For Best Results: Apply to wet hair, gently massage into scalp and hair, lather 1 minute, rinse thoroughly, use daily.Use in combination with Nioxin System 2 Scalp Therapy Conditioner plus Scalp and Hair Treatment

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B000NW84UI |
| ASIN  | B000NW84UI |
| Best Sellers Rank | #21,461 in Beauty ( See Top 100 in Beauty ) #1,068 in Hair Shampoos |
| Customer reviews | 4.6 4.6 out of 5 stars (3,248) |
| Date First Available  | 7 August 2012 |
| Department | womens |
| Department  | womens |
| Is Discontinued By Manufacturer  | No |
| Item model number | 81629280 |
| Item model number  | 81629280 |
| Manufacturer | Nioxin |
| Manufacturer  | Nioxin |
| Product Dimensions | 6.9 x 5.2 x 25 cm; 544.31 g |
| Product Dimensions  | 6.9 x 5.2 x 25 cm; 544.31 g |

## Product Details

- **Age range (description):** Adult
- **Brand:** NIOXIN
- **Hair type:** Thin
- **Item form:** Liquid
- **Scent:** Peppermint Oil

## Images

![Derma Purifying System 2 Cleanser Shampoo (Natural Hair, Progressed Thinning) 500ml/16.9oz - Image 1](https://m.media-amazon.com/images/I/61V20PpFdDL.jpg)

## Questions & Answers

**Q: I bough nioxin system 2 cleanser alone; can i use it daily without conditioner and complete system?**
A: The nioxin I purchased on Amazon, I  believe, was a knockoff. It dried out my hair and almost ruined it. My stylist said that nioxin only sells to salons and not on line.  I will only purchase from a salon from now on.  To answer your queestion, yes you can use it without using the conditioner.

**Q: does it re-grow hair after chemo and radiation?**
A: Yes,but regrow hair may thicken or change color. Good luck!

**Q: My bottle of Nioxin came without a seal. Is this normal?**
A: I have never seen one without a seal.  But the seal was under the cap, and was like a tropicana seal.  I have also bought the big bottles and filled the smaller ones for space.  It would be a shame if that is what happened to you.

**Q: What if your hair is natural at the roots (growing out) and chemically treated a bit on the ends? It is Dry.**
A: I would use the #4 set for color treated hair. It has more moisturizer so your hair won't dry out

## Customer Reviews

### ⭐⭐⭐⭐⭐ Review
*by A***N on 19 December 2025*

Controls hair dandruff, fungus really well. Also works for hair fall. Smells good.👍

### ⭐⭐⭐⭐⭐ Review
*by C***S on 4 January 2025*

El shampoo me ha caído muy bien para mi cuero cabelludo sensible, graso, me lo ha limpiado sin irritarlo y me ha ayudado a que me salga más.

### ⭐⭐⭐⭐⭐ Review
*by M***N on 5 March 2024*

Este producto combinado con otros tratamientos con constancia resulta en eliminar la extrema pérdida de cabello y volver a visualizar más volumen

## Frequently Bought Together

- Nioxin System 2 Scalp + Hair Thickening Shampoo For Natural Hair with Progressed Thinning Boost Hair Density with Niacinamide & Biotin
- Nioxin Density Defend Styling Root Lifting Spray | Hair Thickening Spray | Texturizes and Volumizes | 5.1 Fl oz.
- Nioxin Hair Fall Defense Intensive Daily Leave-In Hair Treatment | With Niacinamide, Caffeine, Lauric Acid, and Sandalore | For Thicker, Stronger Hair | 2.3 Fl Oz.

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*Product available on Desertcart South Africa*
*Store origin: ZA*
*Last updated: 2026-02-22*