--- product_id: 247862108 title: "N1O1 Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz" brand: "n1o1" price: "R4477" currency: ZAR in_stock: true reviews_count: 8 category: "N1 O1" url: https://www.desertcart.co.za/products/247862108-n1o1-nitric-oxide-activating-anti-aging-face-serum-20-vitamin store_origin: ZA region: South Africa --- # 20% stable Vitamin C antioxidant power Hydrates & moisturizes deeply Nobel Prize-winning Nitric Oxide activation N1O1 Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz **Brand:** n1o1 **Price:** R4477 **Availability:** ✅ In Stock ## Summary > ✨ Unlock your skin’s youthful glow with Nobel Prize-winning science! ## Quick Answers - **What is this?** N1O1 Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz by n1o1 - **How much does it cost?** R4477 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.co.za](https://www.desertcart.co.za/products/247862108-n1o1-nitric-oxide-activating-anti-aging-face-serum-20-vitamin) ## Best For - n1o1 enthusiasts ## Why This Product - Trusted n1o1 brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Effortless Daily Ritual:** Quick-absorbing serum that fits seamlessly into your morning and evening skincare routine. - • **Visible Skin Transformation:** Clinically shown to reduce wrinkles, dark spots & fine lines for a smoother, brighter complexion. - • **Dual-Chamber Delivery System:** Innovative design ensures fresh, potent ingredients activate on contact for maximum efficacy. - • **Universal Skin Compatibility:** Gentle, effective formula suitable for all skin types including sensitive skin. - • **Science-Backed Anti-Aging Power:** Harnesses Nitric Oxide + 20% Vitamin C to target aging at its root. ## Overview N1O1 Nitric Oxide Activating Anti-Aging Face Serum combines a patented dual-chamber formula delivering 20% stable Vitamin C and Nitric Oxide to stimulate collagen, boost hydration, and neutralize free radicals. Clinically validated in 4 studies, this fragrance-free, vegan serum visibly reduces wrinkles, dark spots, and fine lines while supporting even skin tone. Suitable for all skin types, it offers a 30-day supply of dermatologist-recommended anti-aging care that activates the skin’s natural rejuvenation process. ## Description N1O1 is the first anti-aging skin care serum that uses the Nobel Prize-winning discovery of Nitric Oxide in combination with 20% vitamin c to defy aging skin by correcting the cause of aging and help reduce the appearance of wrinkles, dark spots and fine lines. N1o1 stimulates collagen production and may support the youthful flow of oxygen, hydration, and nutrients to your skin cells. The problem is our body makes less Nitric Oxide as we get older. This is the reason your skin ages. Loss of Nitric Oxide = Accelerating Aging. N1o1 helps restore the missing Nitric Oxide to get to the root cause of aging skin. The result: wrinkles and dark spots disappear, tone improves and you’ll love the way your skin looks and feels. The results are backed by 20 years of research and science and proven effective in 4 Clinical Studies. Nitric Oxide is a molecule produced by the human body. As we age, Nitric Oxide production diminishes by as much as 50% by age 40. Science has proven that the loss of Nitric Oxide production accelerates the aging process from cardiovascular function to the signs of aging of the skin. N1o1's unique patent-pending formula contains powerful antioxidant ingredients including 20% Vitamin C and it’s dual-chamber delivery system generates nitric oxide molecules you can actually see working on the skin within seconds. By activating nitric oxide production at the surface of the skin and within the dermis, the skin is in an optimally receptive state. Nitric Oxide is so important to human health and aging that its discovery led to a Nobel Prize in Physiology & Medicine 1998. Apply 1x daily proactively in your 20's, 1 - 2 x daily for aging and damaged skin in your 40's; Dermatologists and Skin Care professionals recommend 2x daily for damaged and aging skin. Use N1O1 for wrinkles, pore size, skin town, skin texture, clarity, dark spots and more. Review: This is the one to buy!! I've tested many expensive ones!! - As I started seeing changes in my skin, I searched for solutions and was influenced into buying multiple products that had no ROI, I don't expect results over night, in fact I believe if you're using a topical, it might take months and multiple bottles to start seeing changes. That said, I still get a feel for a product earlier on. I bought this after I watched a podcast with the doctor who invented it and felt he was sincere and skilled (knowing the science is a far cry from product development) I had been frustrated with a different product (more expensive with terrible packaging) I bought this and on the first application I felt it was "real", by the first week I can see better skin emerging, I'm still mid first bottle, and now want to order more products from them. Some days I see results more than others, but I know without a doubt this works!! I'm excited to see the changes over time. The one feedback I would give the brand is on packaging, the vitamin C side sort of sprays out at times, not that it wastes product but feels like I get less than the other side. so be mindful of that when you use it. **bottom line: This is effective, absorbs right away, I barely wait to moisturize after, and I think you get a good amount for the money. -Cons: Not a true con but packaging could be better but I understand they want to control dosing, I just feel viscosity is different on both sides therefore it should be a different dispenser. This will not stop me from buying again and I HIGHLY RECOMMEND THIS!! Buy this so you start seeing results, it's refreshing Review: It’s worth the $100 - I was having horrible skin months, maybe years, red blotchy broken out, dry patches I kept digging at it and it refused to heal or retain moisture. My 30’s were mixed skin but my 40’s were just bad, bag on head horrendous. I bought it on a Sat same day delivery. I’m shocked, near 6 days later I’m writing a review. The dry patches are gone. The breakouts gone. The redness and scars are slower to respond but, I think eventually that will fade as well. If I can ditch makeup I’d call this a complete game changer. My skin did lightly flush initially but it goes away quickly for me. I’m excited to see what a month out looks like. These pictures are a 7 days using the serum post wash twice a day followed by my normal moisturizer. Maintaining my makeup routine. This comes highly recommended by me! ## Features - Hydrating And Moisturizing: Our moisturizing face serum combines Nitric Oxide with Vitamin C to bring you a facial serum that will help support smooth, supple and soft skin without relying on any harsh chemicals or additives for day to day skincare - Brighter And Smoother Skin: Our facial skin care serum with Nitric Oxide helps support collagen, hydration, and nutrient flow to your skin to help reduce the visibility of fine lines, dark spots, and other signs of aging without relying on any harsh chemicals or additives - Even Skin Tone Support: This skin brightening serum contains 20% stable Vitamin C that not only helps moisturize the skin but also helps provide antioxidant support to help reduce oxidative stress by helping neutralize free-radicals to support an even and brighter skin tone - Suitable For All Skin Types: The vitamin C face serum utilizes Nitric Oxide along with a balanced formula to help support the skin without relying on any harsh chemicals. This nitric oxide and Vitamin C serum is suitable for dry, oily, normal, and sensitive skin to offer gentle support - Simple To Use: Each bottle of activating serum can provide up to a 30 day supply. Simply apply a single pump of serum to your palm, gently massage it onto your face and neck, and let it rest for 1-2 minutes. Our vitamin C serum can be applied both during the day and night ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B08LNTJZST | | Active Ingredients | vitamin_c | | Best Sellers Rank | #54,535 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #1,097 in Facial Serums | | Brand | N1O1 | | Brand Name | N1O1 | | Customer Reviews | 4.1 out of 5 stars 335 Reviews | | Item Form | Serum | | Item Highlight | Developed by Dr. Nathan S Bryan, Hydrating Serum, Minimizes Dark Spots, Promotes Smoother-Looking Skin, Reduces Fine Lines | | Item Volume | 1 fluid ounces | | Manufacturer | Pneuma Nitric Oxide | | Manufacturer Part Number | n1o1 | | Material Features | Cruelty Free, Fragrance Free, GMO Free, Gluten Free, Vegan | | Material Type Free | Paraben Free, Phthalate Free | | Model Number | n1o1 | | Number of Items | 1 | | Product Benefits | Anti-Aging | | Recommended Uses For Product | Before Cream | | Scent | Fragrance Free | | Scent Name | Fragrance Free | | Skin Type | All | | Special Ingredients | Antioxidants, Vitamin C, Vitamin E | | Target Use Body Part | Face | | UPC | 608597658903 | | Unit Count | 1 Fluid Ounces | | Use for | Face | ## Product Details - **Product Benefits:** Anti-Aging - **Scent:** Fragrance Free - **Skin Type:** All - **Special Ingredients:** Antioxidants, Vitamin C, Vitamin E - **Use for:** Face ## Images ![N1O1 Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz - Image 1](https://m.media-amazon.com/images/I/519vaxPub-L.jpg) ![N1O1 Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz - Image 2](https://m.media-amazon.com/images/I/61zL1eeO5OL.jpg) ![N1O1 Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz - Image 3](https://m.media-amazon.com/images/I/71Y3NqR5KSL.jpg) ![N1O1 Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz - Image 4](https://m.media-amazon.com/images/I/71kcr2EbLrL.jpg) ![N1O1 Nitric Oxide Activating Anti-Aging Face Serum, 20% Vitamin C, 1 Fl Oz - Image 5](https://m.media-amazon.com/images/I/7104ukq6FyL.jpg) ## Questions & Answers **Q: What color is the serum supposed to be directly out of the bottle?** A: The bottle is a dual chamber system - one side of the bottle contains vitamin C, the other side contains liquid nitric oxide. When you use one pump from each side of the bottle, and mix the drops together in the palm of your hand, the vitamin C acts as the activating ingredient to activate the nitric oxide. The nitric oxide serum is clear, the vitamin C can be an amber color. **Q: Should I use hyaluronic acid in addition to this, or does this replace hyaluronic acid?** A: Thank you for reaching out! You should use Hyaluronic Acid after using our Nitric Oxide Activating Serum. The serum help with the absorption of the HA...and will actually boost it! Hope this helps! **Q: What percentage of nitric oxide?** A: Thank you for asking! The serum is a dual chamber bottle that contains nitrite in one chamber and Vitamin C in the other. The vitamin C is the activating agent which when mixed with the nitrite creates nitric oxide gas. The mixture is 100% nitric oxide. Hope this helps. **Q: is it animal tested?** A: No, our products are never animal tested. ## Customer Reviews ### ⭐⭐⭐⭐⭐ This is the one to buy!! I've tested many expensive ones!! *by C***I on August 9, 2026* As I started seeing changes in my skin, I searched for solutions and was influenced into buying multiple products that had no ROI, I don't expect results over night, in fact I believe if you're using a topical, it might take months and multiple bottles to start seeing changes. That said, I still get a feel for a product earlier on. I bought this after I watched a podcast with the doctor who invented it and felt he was sincere and skilled (knowing the science is a far cry from product development) I had been frustrated with a different product (more expensive with terrible packaging) I bought this and on the first application I felt it was "real", by the first week I can see better skin emerging, I'm still mid first bottle, and now want to order more products from them. Some days I see results more than others, but I know without a doubt this works!! I'm excited to see the changes over time. The one feedback I would give the brand is on packaging, the vitamin C side sort of sprays out at times, not that it wastes product but feels like I get less than the other side. so be mindful of that when you use it. **bottom line: This is effective, absorbs right away, I barely wait to moisturize after, and I think you get a good amount for the money. -Cons: Not a true con but packaging could be better but I understand they want to control dosing, I just feel viscosity is different on both sides therefore it should be a different dispenser. This will not stop me from buying again and I HIGHLY RECOMMEND THIS!! Buy this so you start seeing results, it's refreshing ### ⭐⭐⭐⭐⭐ It’s worth the $100 *by C***G on May 15, 2026* I was having horrible skin months, maybe years, red blotchy broken out, dry patches I kept digging at it and it refused to heal or retain moisture. My 30’s were mixed skin but my 40’s were just bad, bag on head horrendous. I bought it on a Sat same day delivery. I’m shocked, near 6 days later I’m writing a review. The dry patches are gone. The breakouts gone. The redness and scars are slower to respond but, I think eventually that will fade as well. If I can ditch makeup I’d call this a complete game changer. My skin did lightly flush initially but it goes away quickly for me. I’m excited to see what a month out looks like. These pictures are a 7 days using the serum post wash twice a day followed by my normal moisturizer. Maintaining my makeup routine. This comes highly recommended by me! ### ⭐ Allergic Reaction - No Go *by K***N on March 11, 2026* This serum broke my face and neck out with red bumps and itchy skin. I wasn't sure if it was the product so I stayed off of it for a week and then used it one more time. Huge allergic reaction and has caused me to have itchy skin and irritated skin. I do not like this product for me. I ordered it based on a segment shown on DayStar TV. Apparently Joni uses it but I can not tolerate the product. ## Frequently Bought Together - Nitric Oxide Activating Serum with Antioxidants | Hydrating Serum For Face | Decreases Wrinkles | Pore Minimizer | Improves Skin Texture | Helps Dark Spots | 1 Fl Oz, 30ml - N1O1 Nitric Oxide Lozenges - 60 Count - Nitric Oxide Supplement for Heart Health, Circulation, Energy, Blood Flow, Oxygenation, Healthy Blood Pressure, Cardiovascular Support for Men & Women - N1O1 Moisturizer Face Cream - Day & Night Face Moisturizer with Nitric Oxide, Peptide Complex, Epidermal Growth Factor - Tightening & Firming Skin Care Products for Wrinkles, Dark Spots - 1.75 oz. --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.co.za/products/247862108-n1o1-nitric-oxide-activating-anti-aging-face-serum-20-vitamin](https://www.desertcart.co.za/products/247862108-n1o1-nitric-oxide-activating-anti-aging-face-serum-20-vitamin) --- *Product available on Desertcart South Africa* *Store origin: ZA* *Last updated: 2026-09-21*